A tumour gene's fatal flaws

Julian Downward
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Julian Downward: Julian Downward is at Cancer Research UK London Research Institute, 44 Lincoln's Inn Fields, London WC2A 3PX, UK. downward@cancer.org.uk

Nature, 2009, vol. 462, issue 7269, 44-45

Abstract: Mutations in RAS genes are common in human tumours, but RAS has proved impossible to target with drugs. Its associated NF-κB signalling pathway, however, may turn out to be this tumour gene's Achilles heel.

Date: 2009
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DOI: 10.1038/462044a

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