Effector T cell interactions with meningeal vascular structures in nascent autoimmune CNS lesions

Ingo Bartholomäus, Naoto Kawakami, Francesca Odoardi, Christian Schläger, Djordje Miljkovic, Joachim W. Ellwart, Wolfgang E. F. Klinkert, Cassandra Flügel-Koch, Thomas B. Issekutz, Hartmut Wekerle () and Alexander Flügel ()
Additional contact information
Ingo Bartholomäus: Max Planck Institute for Neurobiology
Naoto Kawakami: Max Planck Institute for Neurobiology
Francesca Odoardi: Max Planck Institute for Neurobiology
Christian Schläger: Max Planck Institute for Neurobiology
Djordje Miljkovic: Max Planck Institute for Neurobiology
Joachim W. Ellwart: Institute for Experimental Hematology, Helmholtz Centre, 81377 Munich, Germany
Wolfgang E. F. Klinkert: Max Planck Institute for Neurobiology
Cassandra Flügel-Koch: Institute for Anatomy 2, Friedrich-Alexander-University
Thomas B. Issekutz: Dalhousie University, Halifax, Nova Scotia B3K 6R8, Canada
Hartmut Wekerle: Max Planck Institute for Neurobiology
Alexander Flügel: Max Planck Institute for Neurobiology

Nature, 2009, vol. 462, issue 7269, 94-98

Abstract: T cells in autoimmunity A two-photon fluorescence microscopy study of rats with experimental autoimmune encephalomyelitis — a model for multiple sclerosis — shows autoimmune-disease-triggering blood T cells first directly attaching and then scanning the internal surface of the spinal meningeal vasculature, sometimes crawling against the direction of blood flow. Once across the blood–brain barrier, the T cells engage with antigen-presenting phagocytes that in turn stimulate their further differentiation and tissue infiltration. The structures involved in these interactions with T cells could be potential candidate targets for therapy against autoimmune brain disease.

Date: 2009
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DOI: 10.1038/nature08478

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