HMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responses

Hideyuki Yanai, Tatsuma Ban, ZhiChao Wang, Myoung Kwon Choi, Takeshi Kawamura, Hideo Negishi, Makoto Nakasato, Yan Lu, Sho Hangai, Ryuji Koshiba, David Savitsky, Lorenza Ronfani, Shizuo Akira, Marco E. Bianchi, Kenya Honda, Tomohiko Tamura, Tatsuhiko Kodama and Tadatsugu Taniguchi ()
Additional contact information
Hideyuki Yanai: Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan
Tatsuma Ban: Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan
ZhiChao Wang: Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan
Myoung Kwon Choi: Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan
Takeshi Kawamura: Laboratory for System Biology and Medicine, RCAST, University of Tokyo, Komaba 4-6-1, Meguro-ku, Tokyo 153-8904, Japan
Hideo Negishi: Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan
Makoto Nakasato: Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan
Yan Lu: Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan
Sho Hangai: Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan
Ryuji Koshiba: Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan
David Savitsky: Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan
Lorenza Ronfani: Faculty of Medicine, San Raffaele University, via Olgettina 58, 20132 Milan, Italy
Shizuo Akira: Laboratory of Host Defense, WPI Immunology Frontier Research Center, Osaka University, Yamada-oka 3-1, Suita, Osaka 565-0871, Japan
Marco E. Bianchi: Faculty of Medicine, San Raffaele University, via Olgettina 58, 20132 Milan, Italy
Kenya Honda: Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan
Tomohiko Tamura: Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan
Tatsuhiko Kodama: Laboratory for System Biology and Medicine, RCAST, University of Tokyo, Komaba 4-6-1, Meguro-ku, Tokyo 153-8904, Japan
Tadatsugu Taniguchi: Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan

Nature, 2009, vol. 462, issue 7269, 99-103

Abstract: HMGB protein sentinels The chromosomal HMGB (high-mobility group box) proteins HMGB1, HMGB2 and HMGB3 are shown here to be essential for all nucleic-acid receptor-mediated activation of innate immune responses. HMGBs bound to all immunogenic nucleic acids tested — whether considered ligands for Toll-like receptors or for cytosolic receptors — suggesting that they may have a physiological role as universal sentinels for intracellular nucleic acids.

Date: 2009
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DOI: 10.1038/nature08512

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