Bidirectional plasticity in fast-spiking GABA circuits by visual experience

Yoko Yazaki-Sugiyama, Siu Kang, Hideyuki Câteau, Tomoki Fukai and Takao K. Hensch ()
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Yoko Yazaki-Sugiyama: CREST, JST, Toyonaka, Osaka 560-0082, Japan
Siu Kang: Laboratory for Neural Circuit Theory, RIKEN Brain Science Institute, 2-1 Hirosawa, Wako-shi, Saitama 351-0198, Japan
Hideyuki Câteau: Laboratory for Neural Circuit Theory, RIKEN Brain Science Institute, 2-1 Hirosawa, Wako-shi, Saitama 351-0198, Japan
Tomoki Fukai: Laboratory for Neural Circuit Theory, RIKEN Brain Science Institute, 2-1 Hirosawa, Wako-shi, Saitama 351-0198, Japan
Takao K. Hensch: CREST, JST, Toyonaka, Osaka 560-0082, Japan

Nature, 2009, vol. 462, issue 7270, 218-221

Abstract: How visual experience influences the brain Experience can induce robust plasticity in brain areas processing sensory information, but the influence of modified individual circuit elements on the network as a whole is largely unknown. New experiments analysed activity from within individual cells in parts of the visual circuit and found that upon monocular deprivation, cells initially bias their response preference toward the occluded eye, and only later shift to the open eye. This seemed to occur due to the ever-shifting balance between excitation and inhibition modulating the activity of individual neurons. Thus, inhibitory circuits play a major role in shaping experience-dependent plasticity in the developing visual cortex.

Date: 2009
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DOI: 10.1038/nature08485

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