Uptake through glycoprotein 2 of FimH+ bacteria by M cells initiates mucosal immune response

Koji Hase, Kazuya Kawano, Tomonori Nochi, Gemilson Soares Pontes, Shinji Fukuda, Masashi Ebisawa, Kazunori Kadokura, Toru Tobe, Yumiko Fujimura, Sayaka Kawano, Atsuko Yabashi, Satoshi Waguri, Gaku Nakato, Shunsuke Kimura, Takaya Murakami, Mitsutoshi Iimura, Kimiyo Hamura, Shin-Ichi Fukuoka, Anson W. Lowe, Kikuji Itoh, Hiroshi Kiyono and Hiroshi Ohno ()
Additional contact information
Koji Hase: Laboratory for Epithelial Immunobiology, Research Center for Allergy and Immunology, RIKEN, Kanagawa 230-0045, Japan
Kazuya Kawano: Laboratory for Epithelial Immunobiology, Research Center for Allergy and Immunology, RIKEN, Kanagawa 230-0045, Japan
Tomonori Nochi: The Institute of Medical Science, The University of Tokyo
Gemilson Soares Pontes: The Institute of Medical Science, The University of Tokyo
Shinji Fukuda: Laboratory for Epithelial Immunobiology, Research Center for Allergy and Immunology, RIKEN, Kanagawa 230-0045, Japan
Masashi Ebisawa: Laboratory for Epithelial Immunobiology, Research Center for Allergy and Immunology, RIKEN, Kanagawa 230-0045, Japan
Kazunori Kadokura: Laboratory for Epithelial Immunobiology, Research Center for Allergy and Immunology, RIKEN, Kanagawa 230-0045, Japan
Toru Tobe: Graduate School of Medicine, Osaka University, 565-0871 Suita, Osaka, Japan
Yumiko Fujimura: Laboratory for Epithelial Immunobiology, Research Center for Allergy and Immunology, RIKEN, Kanagawa 230-0045, Japan
Sayaka Kawano: Laboratory for Epithelial Immunobiology, Research Center for Allergy and Immunology, RIKEN, Kanagawa 230-0045, Japan
Atsuko Yabashi: Fukushima Medical University, School of Medicine
Satoshi Waguri: Fukushima Medical University, School of Medicine
Gaku Nakato: Laboratory for Epithelial Immunobiology, Research Center for Allergy and Immunology, RIKEN, Kanagawa 230-0045, Japan
Shunsuke Kimura: Laboratory for Epithelial Immunobiology, Research Center for Allergy and Immunology, RIKEN, Kanagawa 230-0045, Japan
Takaya Murakami: Laboratory for Epithelial Immunobiology, Research Center for Allergy and Immunology, RIKEN, Kanagawa 230-0045, Japan
Mitsutoshi Iimura: Institute of Gastroenterology, Tokyo Women’s Medical University
Kimiyo Hamura: Institute of Gastroenterology, Tokyo Women’s Medical University
Shin-Ichi Fukuoka: College of Science and Engineering, Aoyama Gakuin University, Kanagawa, 229-8558, Japan
Anson W. Lowe: Stanford University, Stanford, California 94305, USA
Kikuji Itoh: Veterinary Public Health, Graduate School of Agricultural and Life Sciences, The University of Tokyo
Hiroshi Kiyono: The Institute of Medical Science, The University of Tokyo
Hiroshi Ohno: Laboratory for Epithelial Immunobiology, Research Center for Allergy and Immunology, RIKEN, Kanagawa 230-0045, Japan

Nature, 2009, vol. 462, issue 7270, 226-230

Abstract: M cells in immunity The mucosal immune system plays a major role in protecting mucosal surfaces against pathogens and also in promoting co-habitation with commensal microflora. To evoke the mucosal immune response, antigens on the mucosal surface must first cross the impermeable epithelial barrier into lymphoid structures such as Peyer's patches. This function, called antigen transcytosis, is thought to be mediated mainly by M cells, specialized epithelial cells in the Peyer's patches. A study of the mechanisms underlying antigen transcytosis by M cells shows that glycoprotein-2, expressed on the apical side of intestinal M cells, is the transcytotic receptor for bacteria expressing the FimH antigen. As M cells are considered a promising target for various oral vaccinations, this work points to glycoprotein-2-dependent transcytosis as a possible vaccine target.

Date: 2009
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DOI: 10.1038/nature08529

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