Human-specific transcriptional regulation of CNS development genes by FOXP2

Genevieve Konopka (), Jamee M. Bomar, Kellen Winden, Giovanni Coppola, Zophonias O. Jonsson, Fuying Gao, Sophia Peng, Todd M. Preuss, James A. Wohlschlegel and Daniel H. Geschwind ()
Additional contact information
Genevieve Konopka: Program in Neurogenetics,
Jamee M. Bomar: Program in Neurogenetics,
Kellen Winden: Program in Neurogenetics,
Giovanni Coppola: Departments of Neurology,
Zophonias O. Jonsson: Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
Fuying Gao: Departments of Neurology,
Sophia Peng: Departments of Neurology,
Todd M. Preuss: Yerkes National Primate Research Center, Emory University School of Medicine, Atlanta, Georgia 30329, USA
James A. Wohlschlegel: Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
Daniel H. Geschwind: Program in Neurogenetics,

Nature, 2009, vol. 462, issue 7270, 213-217

Abstract: Speech, FOXP2 and the human–chimp divide The transcription factor FOXP2 is the only gene so far to have been implicated in human speech, yet it differs very little from the chimpanzee equivalent. New experiments reveal differences between the activation of downstream transcriptional targets of FOXP2 in humans and chimpanzees arising from the two amino acid differences between the two forms of FOXP2. The different gene network interactions influenced by each version of FOXP2 are also reflected in the non-overlapping brain expression patterns exhibited by chimps and humans. These data provide support for the idea that evolutionary changes to FOXP2 in the human lineage have direct consequences for human brain development and disease in the central nervous system and may have a critical role in the development of language circuitry in humans.

Date: 2009
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DOI: 10.1038/nature08549

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