CD8+ T lymphocyte mobilization to virus-infected tissue requires CD4+ T-cell help

Yusuke Nakanishi, Bao Lu, Craig Gerard and Akiko Iwasaki ()
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Yusuke Nakanishi: Yale University School of Medicine, New Haven, Connecticut 06520, USA
Bao Lu: Children’s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Craig Gerard: Children’s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Akiko Iwasaki: Yale University School of Medicine, New Haven, Connecticut 06520, USA

Nature, 2009, vol. 462, issue 7272, 510-513

Abstract: A new way to help Successful defence against intracellular pathogens requires neutralizing antibodies and cytotoxic CD8+ T lymphocyte (CTL) responses, both largely dependent on the activity of CD4+ T helper cells. Nakanishi et al. report a previously unrecognized aspect of CD4 help in the CTL response: CD4+ T cells are required for the recruitment of CD8+ T cells to mucosal sites of viral infection. The CD4+ T-cell help requires the secretion of interferon-γ and the induction of local chemokine secretion.

Date: 2009
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DOI: 10.1038/nature08511

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