Rapid formation and selective stabilization of synapses for enduring motor memories

Tonghui Xu, Xinzhu Yu, Andrew J. Perlik, Willie F. Tobin, Jonathan A. Zweig, Kelly Tennant, Theresa Jones and Yi Zuo ()
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Tonghui Xu: Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, California 95064, USA
Xinzhu Yu: Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, California 95064, USA
Andrew J. Perlik: Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, California 95064, USA
Willie F. Tobin: Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, California 95064, USA
Jonathan A. Zweig: Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, California 95064, USA
Kelly Tennant: Institute for Neuroscience, University of Texas at Austin, Austin, Texas 78712, USA
Theresa Jones: Institute for Neuroscience, University of Texas at Austin, Austin, Texas 78712, USA
Yi Zuo: Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, California 95064, USA

Nature, 2009, vol. 462, issue 7275, 915-919

Abstract: Synapse structure in memory: changes within hours Long-term memories for motor skill tasks are associated with enhanced synaptic efficacy in the motor cortex. Here, rapid structural responses in individual neurons are revealed to potentially underlie motor learning skill retention. In experiments in which mice were trained to perform a reaching task, new neuronal spines were selectively stabilized within hours, with different spines/putative synapse sets encoding distinct learned motor skills. These stabilized morphological changes are proposed to act as a motor memory substrate.

Date: 2009
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DOI: 10.1038/nature08389

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