Coordinating DNA replication by means of priming loop and differential synthesis rate

Manjula Pandey, Salman Syed, Ilker Donmez, Gayatri Patel, Taekjip Ha () and Smita S. Patel ()
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Manjula Pandey: University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
Salman Syed: Howard Hughes Medical Institute, Urbana, Illinois 61801, USA
Ilker Donmez: University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
Gayatri Patel: University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
Taekjip Ha: Howard Hughes Medical Institute, Urbana, Illinois 61801, USA
Smita S. Patel: University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA

Nature, 2009, vol. 462, issue 7275, 940-943

Abstract: Two sides of DNA replication DNA is replicated by a replisome containing two polymerases that move unidirectionally, sythesizing DNA strands of opposite polarity. DNA synthesis on the leading and lagging strands therefore involves different mechanisms, although the rate of synthesis is coordinated so that movement on the two strands is equal. A previous study suggested that the leading-strand polymerase pauses when the lagging-strand polymerase synthesizes a new primer for each Okazaki fragment. Patel et al. now find no evidence for pausing; rather, they find that primers are made as DNA is being synthesized and then passed on to the polymerase. To allow for this transfer, the lagging-strand polymerase copies DNA at a faster rate than the leading strand.

Date: 2009
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DOI: 10.1038/nature08611

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