E2f1–3 switch from activators in progenitor cells to repressors in differentiating cells

Jean-Leon Chong, Pamela L. Wenzel, M. Teresa Sáenz-Robles, Vivek Nair, Antoney Ferrey, John P. Hagan, Yorman M. Gomez, Nidhi Sharma, Hui-Zi Chen, Madhu Ouseph, Shu-Huei Wang, Prashant Trikha, Brian Culp, Louise Mezache, Douglas J. Winton, Owen J. Sansom, Danian Chen, Rod Bremner, Paul G. Cantalupo, Michael L. Robinson, James M. Pipas and Gustavo Leone ()
Additional contact information
Jean-Leon Chong: Immunology and Medical Genetics, College of Medicine
Pamela L. Wenzel: Immunology and Medical Genetics, College of Medicine
M. Teresa Sáenz-Robles: University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
Vivek Nair: Immunology and Medical Genetics, College of Medicine
Antoney Ferrey: Immunology and Medical Genetics, College of Medicine
John P. Hagan: Immunology and Medical Genetics, College of Medicine
Yorman M. Gomez: Immunology and Medical Genetics, College of Medicine
Nidhi Sharma: Immunology and Medical Genetics, College of Medicine
Hui-Zi Chen: Immunology and Medical Genetics, College of Medicine
Madhu Ouseph: Immunology and Medical Genetics, College of Medicine
Shu-Huei Wang: Immunology and Medical Genetics, College of Medicine
Prashant Trikha: Immunology and Medical Genetics, College of Medicine
Brian Culp: Immunology and Medical Genetics, College of Medicine
Louise Mezache: Immunology and Medical Genetics, College of Medicine
Douglas J. Winton: Cambridge Research Institute, Li Ka Shing Centre, Cambridge CB2 0RE, UK
Owen J. Sansom: The Beatson Institute for Cancer Research
Danian Chen: Toronto Western Research Institute, University Health Network, and Laboratory Medicine and Pathobiology, University of Toronto
Rod Bremner: Toronto Western Research Institute, University Health Network, and Laboratory Medicine and Pathobiology, University of Toronto
Paul G. Cantalupo: University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
Michael L. Robinson: Miami University, Oxford, Ohio 45056, USA
James M. Pipas: University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
Gustavo Leone: Immunology and Medical Genetics, College of Medicine

Nature, 2009, vol. 462, issue 7275, 930-934

Abstract: E2f transcription factors The in vivo function of E2f transcription factors has been a matter of debate. Here it is shown that E2f1–3 contribute to the activation of cell cycle genes in dividing progenitor cells during mouse development but are dispensable for cell division. However, in differentiating cells, E2f1–3 act as repressors to facilitate cell cycle exit.

Date: 2009
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DOI: 10.1038/nature08677

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