Secreted semaphorins control spine distribution and morphogenesis in the postnatal CNS

Tracy S. Tran, Maria E. Rubio, Roger L. Clem, Dontais Johnson, Lauren Case, Marc Tessier-Lavigne, Richard L. Huganir, David D. Ginty () and Alex L. Kolodkin ()
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Tracy S. Tran: Solomon H. Snyder Department of Neuroscience,
Maria E. Rubio: University of Connecticut, Storrs, Connecticut 06269, USA
Roger L. Clem: Solomon H. Snyder Department of Neuroscience,
Dontais Johnson: Solomon H. Snyder Department of Neuroscience,
Lauren Case: Graduate Program in Neurosciences, Stanford University, Stanford, California 94305, USA
Marc Tessier-Lavigne: Graduate Program in Neurosciences, Stanford University, Stanford, California 94305, USA
Richard L. Huganir: Solomon H. Snyder Department of Neuroscience,
David D. Ginty: Solomon H. Snyder Department of Neuroscience,
Alex L. Kolodkin: Solomon H. Snyder Department of Neuroscience,

Nature, 2009, vol. 462, issue 7276, 1065-1069

Abstract: Semaphorin signalling Although it is known that different dendritic domains on the same neuron can receive distinct input, the molecular codes underlying these differences have been unknown. Here it is shown that a specific semaphorin signalling pathway, the Sema3F–Npn-2/PlexA4 cascade, that was previously associated with axonal guidance, is involved in the control of dendritic spine development and synapse formation in different dendritic arbours.

Date: 2009
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DOI: 10.1038/nature08628

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