Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma

R. Eric Davis, Vu N. Ngo, Georg Lenz, Pavel Tolar, Ryan M. Young, Paul B. Romesser, Holger Kohlhammer, Laurence Lamy, Hong Zhao, Yandan Yang, Weihong Xu, Arthur L. Shaffer, George Wright, Wenming Xiao, John Powell, Jian-kang Jiang, Craig J. Thomas, Andreas Rosenwald, German Ott, Hans Konrad Muller-Hermelink, Randy D. Gascoyne, Joseph M. Connors, Nathalie A. Johnson, Lisa M. Rimsza, Elias Campo, Elaine S. Jaffe, Wyndham H. Wilson, Jan Delabie, Erlend B. Smeland, Richard I. Fisher, Rita M. Braziel, Raymond R. Tubbs, J. R. Cook, Dennis D. Weisenburger, Wing C. Chan, Susan K. Pierce and Louis M. Staudt ()
Additional contact information
R. Eric Davis: Metabolism Branch,
Vu N. Ngo: Metabolism Branch,
Georg Lenz: Metabolism Branch,
Pavel Tolar: Laboratory of Immunogenetics, National Institute for Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852, USA
Ryan M. Young: Metabolism Branch,
Paul B. Romesser: Metabolism Branch,
Holger Kohlhammer: Metabolism Branch,
Laurence Lamy: Metabolism Branch,
Hong Zhao: Metabolism Branch,
Yandan Yang: Metabolism Branch,
Weihong Xu: Metabolism Branch,
Arthur L. Shaffer: Metabolism Branch,
George Wright: Biometric Research Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Wenming Xiao: Bioinformatics and Molecular Analysis Section, Center for Information Technology, National Institutes of Health, Bethesda, Maryland 20892, USA
John Powell: Bioinformatics and Molecular Analysis Section, Center for Information Technology, National Institutes of Health, Bethesda, Maryland 20892, USA
Jian-kang Jiang: NIH Chemical Genomics Center, National Human Genome Research Institute, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, USA
Craig J. Thomas: NIH Chemical Genomics Center, National Human Genome Research Institute, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, USA
Andreas Rosenwald: University of Würzburg
German Ott: Robert-Bosch-Krankenhaus, and Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology
Hans Konrad Muller-Hermelink: University of Würzburg
Randy D. Gascoyne: British Columbia Cancer Agency, Vancouver, British Columbia, Canada V5Z 4E6
Joseph M. Connors: British Columbia Cancer Agency, Vancouver, British Columbia, Canada V5Z 4E6
Nathalie A. Johnson: British Columbia Cancer Agency, Vancouver, British Columbia, Canada V5Z 4E6
Lisa M. Rimsza: University of Arizona, Tucson, Arizona 85724, USA
Elias Campo: Hospital Clinic, University of Barcelona
Elaine S. Jaffe: Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Wyndham H. Wilson: Metabolism Branch,
Jan Delabie: Pathology Clinic, Rikshospitalet University Hospital
Erlend B. Smeland: Institute for Cancer Research, Rikshospitalet University Hospital and Center for Cancer Biomedicine, University of Oslo
Richard I. Fisher: Southwest Oncology Group, 24 Frank Lloyd Wright Drive, Ann Arbor, Michigan 48106, USA
Rita M. Braziel: Southwest Oncology Group, 24 Frank Lloyd Wright Drive, Ann Arbor, Michigan 48106, USA
Raymond R. Tubbs: Southwest Oncology Group, 24 Frank Lloyd Wright Drive, Ann Arbor, Michigan 48106, USA
J. R. Cook: Southwest Oncology Group, 24 Frank Lloyd Wright Drive, Ann Arbor, Michigan 48106, USA
Dennis D. Weisenburger: University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
Wing C. Chan: University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
Susan K. Pierce: Laboratory of Immunogenetics, National Institute for Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852, USA
Louis M. Staudt: Metabolism Branch,

Nature, 2010, vol. 463, issue 7277, 88-92

Abstract: B-cell receptors and lymphoma A link between B-cell-receptor (BCR) signalling and human B-cell lymphomas has been inferred from the study of immunoglobulin genes in human lymphomas and from work on mouse models, but more evidence is required to confirm an oncogenic role. New work from Davis et al. shows that chronic activation of BCR signalling is required for the survival of the ABC DLBCL subset of B-cell lymphomas. Somatic mutations in CD29A and CD79B found in these lymphomas appear to contribute to BCR activation.

Date: 2010
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DOI: 10.1038/nature08638

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