Identification of sister chromatids by DNA template strand sequences

Ester Falconer, Elizabeth A. Chavez, Alexander Henderson, Steven S. S. Poon, Steven McKinney, Lindsay Brown, David G. Huntsman and Peter M. Lansdorp ()
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Ester Falconer: Terry Fox Laboratory,
Elizabeth A. Chavez: Terry Fox Laboratory,
Alexander Henderson: Terry Fox Laboratory,
Steven S. S. Poon: Terry Fox Laboratory,
Steven McKinney: Molecular Oncology and Breast Cancer Program, B.C. Cancer Agency, Vancouver, British Columbia V5Z 1L3, Canada
Lindsay Brown: Centre for Translational and Applied Genomics, B.C. Cancer Agency, Vancouver, British Columbia V6H 3Z6, Canada
David G. Huntsman: Centre for Translational and Applied Genomics, B.C. Cancer Agency, Vancouver, British Columbia V6H 3Z6, Canada
Peter M. Lansdorp: Terry Fox Laboratory,

Nature, 2010, vol. 463, issue 7277, 93-97

Abstract: Sister chromatid identification Here Peter Lansdorp and colleagues describe a new technique for the observation of chromatid segregation in mitotic cells in vivo. They find that sister chromatids can be distinguished by virtue of the organization of repetitive DNA relative to major satellite DNA, making it possible to differentially label sister chromatids and study their segregation in dividing cells. They find that whereas sister chromatids appear to be randomly distributed between daughter cells in cultured lung fibroblasts and embryonic stem cells, non-random sister chromatid segregation occurs in a subset of colon crypt epithelial cells.

Date: 2010
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DOI: 10.1038/nature08644

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