The Dbf4–Cdc7 kinase promotes S phase by alleviating an inhibitory activity in Mcm4

Yi-Jun Sheu and Bruce Stillman ()
Additional contact information
Yi-Jun Sheu: Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA
Bruce Stillman: Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA

Nature, 2010, vol. 463, issue 7277, 113-117

Abstract: Dual function of Dbf4–Cdc7 kinase Two cell-cycle-regulated kinase pathways regulate the timing of DNA replication initiation. How one of these, the Dbf4–Cdc7 kinase (DDK), affects replication has been unclear. Yi-Jun Sheu and Bruce Stillman now show that a subunit of the replicative helicase, Mcm4, is the target of DDK. The N-terminal domain of Mcm4 possesses an inhibitory activity that is relieved by DDK phosphorylation. In addition, DDK activity also seems to have a second function in regulating the S-phase checkpoint.

Date: 2010
References: Add references at CitEc
Citations: View citations in EconPapers (5)

Downloads: (external link)
https://www.nature.com/articles/nature08647 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:463:y:2010:i:7277:d:10.1038_nature08647

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature08647

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().