An allosteric mechanism of Rho-dependent transcription termination

Vitaly Epshtein, Dipak Dutta, Joseph Wade and Evgeny Nudler ()
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Vitaly Epshtein: New York University School of Medicine, New York, New York 10016, USA
Dipak Dutta: New York University School of Medicine, New York, New York 10016, USA
Joseph Wade: School of Public Health, University at Albany, Albany, New York 12201, USA
Evgeny Nudler: New York University School of Medicine, New York, New York 10016, USA

Nature, 2010, vol. 463, issue 7278, 245-249

Abstract: Mechanism of Rho-dependent termination of transcription Rho is a general transcription termination factor in bacteria, but the mechanism by which it disrupts the RNA polymerase (RNAP) elongation complex is unknown. Here, Rho is shown to bind tightly to RNAP throughout the transcription cycle, and RNAP is proposed to have an active function in Rho termination through an allosteric mechanism. The overall structure of elongation complexes has been preserved during evolution, from bacteria to humans, suggesting that this allosteric control mechanism may a characteristic of transcription systems in general.

Date: 2010
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DOI: 10.1038/nature08669

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