Long-term potentiation depends on release of d-serine from astrocytes

Christian Henneberger, Thomas Papouin, Stéphane H. R. Oliet () and Dmitri A. Rusakov ()
Additional contact information
Christian Henneberger: UCL Institute of Neurology, University College London
Thomas Papouin: INSERM U862, Neurocentre Magendie
Stéphane H. R. Oliet: INSERM U862, Neurocentre Magendie
Dmitri A. Rusakov: UCL Institute of Neurology, University College London

Nature, 2010, vol. 463, issue 7278, 232-236

Abstract: Role of astrocytes in learning and memory The role of astrocytes in synaptic plasticity has remained controversial. It has been suggested that astrocytes, the star-shaped glial cells found in the brain and spinal cord that were once considered merely passive support cells, are involved in inducing LTP (long-term potentiation) of synaptic transmission — a model for the mechanisms of memory — via the modulation of NMDA-receptor activation and postsynaptic Ca2+ entry. A new study provides more support for that theory by demonstrating that the inhibition of d-serine release from individual astrocytes blocks the potentiation of many nearby neuronal junctions.

Date: 2010
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DOI: 10.1038/nature08673

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