KAP1 controls endogenous retroviruses in embryonic stem cells

Helen M. Rowe, Johan Jakobsson, Daniel Mesnard, Jacques Rougemont, Séverine Reynard, Tugce Aktas, Pierre V. Maillard, Hillary Layard-Liesching, Sonia Verp, Julien Marquis, François Spitz, Daniel B. Constam and Didier Trono ()
Additional contact information
Helen M. Rowe: School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland
Johan Jakobsson: School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland
Daniel Mesnard: School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland
Jacques Rougemont: School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland
Séverine Reynard: School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland
Tugce Aktas: EMBL Heidelberg, Meyerhofstrasse 1, 69117 Heidelberg, Germany
Pierre V. Maillard: School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland
Hillary Layard-Liesching: School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland
Sonia Verp: School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland
Julien Marquis: School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland
François Spitz: EMBL Heidelberg, Meyerhofstrasse 1, 69117 Heidelberg, Germany
Daniel B. Constam: School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland
Didier Trono: School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland

Nature, 2010, vol. 463, issue 7278, 237-240

Abstract: Endogenous retroviruses in embryonic stem cells Almost half of the mammalian genome is derived from virus-like entities called retroelements, many of them the result of the incorporation of endogenous retroviruses. Didier Trono and colleagues use a combination of genetic, functional and biochemical analyses to demonstrate that KRAB-associated protein 1 (KAP1)-mediated epigenetic regulation is involved in the early embryonic silencing of intracisternal A particles (IAPs), a still active and highly polymorphic subset of endogenous retroviruses. This work establishes a role for the KAP1 co-repressor in the control of endogenous retroelements during early embryonic development.

Date: 2010
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DOI: 10.1038/nature08674

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