Essentiality of FASII pathway for Staphylococcus aureus

Wendy Balemans, Nacer Lounis, Ron Gilissen, Jerome Guillemont, Kenny Simmen, Koen Andries and Anil Koul
Additional contact information
Wendy Balemans: Tibotec BVBA, Johnson & Johnson, Turnhoutseweg 30, B-2340 Beerse, Belgium. akoul@its.jnj.com
Nacer Lounis: Tibotec BVBA, Johnson & Johnson, Turnhoutseweg 30, B-2340 Beerse, Belgium. akoul@its.jnj.com
Ron Gilissen: Pharmaceutical Research and Development, Johnson & Johnson, Turnhoutseweg 30, B-2340 Beerse, Belgium
Jerome Guillemont: Centre de Recherche Janssen-Cilag, Johnson & Johnson, Campus de Maigremont BP615, F-27106 Val de Reuil cedex, France
Kenny Simmen: Tibotec BVBA, Johnson & Johnson, Gen. De Wittelaan L 11B 3, B-2800 Mechelen, Belgium
Koen Andries: Tibotec BVBA, Johnson & Johnson, Turnhoutseweg 30, B-2340 Beerse, Belgium. akoul@its.jnj.com
Anil Koul: Tibotec BVBA, Johnson & Johnson, Turnhoutseweg 30, B-2340 Beerse, Belgium. akoul@its.jnj.com

Nature, 2010, vol. 463, issue 7279, E3-E3

Abstract: Abstract Arising from: S. Brinster et al. Nature 458, 83–86 (2009)10.1038/nature07772 ; Brinster et al. reply Recently, Brinster et al.1 suggested that type II fatty-acid biosynthesis (FASII) is not a suitable antibacterial target for Gram-positive pathogens because they use fatty acids directly from host serum rather than de novo synthesis. Their findings, if confirmed, are relevant for further scientific and financial investments in the development of new drugs targeting FASII. We present here in vitro and in vivo data demonstrating that their observations do not hold for Staphylococcus aureus, a major Gram-positive pathogen causing several human infections. The observed differences among Gram-positive pathogens in FASII reflects heterogeneity either in fatty-acid synthesis or in the capacity for fatty-acid uptake from the environment.

Date: 2010
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DOI: 10.1038/nature08667

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