Brinster et al. reply

Sophie Brinster, Gilles Lamberet (), Bart Staels, Patrick Trieu-Cuot, Alexandra Gruss () and Claire Poyart
Additional contact information
Sophie Brinster: * Institut Cochin, Université Paris Descartes, CNRS (UMR 8104), 75014 Paris, France. claire.poyart@cch.aphp.fr
Gilles Lamberet: INRA U888, Unité des Bactéries Lactiques et Pathogènes Opportunistes
Bart Staels: § Institut Pasteur de Lille, INSERM UMR545, Université Lille 2, 59019 Lille, France
Patrick Trieu-Cuot: ‖ Institut Pasteur, Unité de Biologie des Bactéries Pathogènes à Gram Positif, URA CNRS 2172, 75015 Paris, France
Alexandra Gruss: INRA U888, Unité des Bactéries Lactiques et Pathogènes Opportunistes
Claire Poyart: * Institut Cochin, Université Paris Descartes, CNRS (UMR 8104), 75014 Paris, France. claire.poyart@cch.aphp.fr

Nature, 2010, vol. 463, issue 7279, E4-E4

Abstract: Abstract Replying to: W. Balemans et al. Nature 462, 10.1038/nature08667 (2009) Our studies led us to conclude that growth of major Gram-positive pathogens, including Staphylococcus aureus, is not inhibited by FASII-targeted antibiotics in septicaemic infection, owing to compensation by serum fatty acids1. The comments of Balemans et al. 2 challenge the generality of our results, mainly on the basis of their own work, which is aimed at developing FabI inhibitors for treatment of S. aureus infections. Their allusion to the documented use of FASII inhibitors to treat mycobacterial infections is misleading. Mycobacteria were not considered in our study, because (1) their main route of pathogenesis is not sepsis, and (2) they require mycolic acids for normal growth, which are lacking in serum. The results we present here further reinforce the conclusions of our article.

Date: 2010
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DOI: 10.1038/nature08668

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