Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes

Gillian L. Dalgliesh, Kyle Furge, Chris Greenman, Lina Chen, Graham Bignell, Adam Butler, Helen Davies, Sarah Edkins, Claire Hardy, Calli Latimer, Jon Teague, Jenny Andrews, Syd Barthorpe, Dave Beare, Gemma Buck, Peter J. Campbell, Simon Forbes, Mingming Jia, David Jones, Henry Knott, Chai Yin Kok, King Wai Lau, Catherine Leroy, Meng-Lay Lin, David J. McBride, Mark Maddison, Simon Maguire, Kirsten McLay, Andrew Menzies, Tatiana Mironenko, Lee Mulderrig, Laura Mudie, Sarah O’Meara, Erin Pleasance, Arjunan Rajasingham, Rebecca Shepherd, Raffaella Smith, Lucy Stebbings, Philip Stephens, Gurpreet Tang, Patrick S. Tarpey, Kelly Turrell, Karl J. Dykema, Sok Kean Khoo, David Petillo, Bill Wondergem, John Anema, Richard J. Kahnoski, Bin Tean Teh (), Michael R. Stratton () and P. Andrew Futreal ()
Additional contact information
Gillian L. Dalgliesh: Cancer Genome Project, Wellcome Trust Sanger Institute
Kyle Furge: Laboratory of Computational Biology,
Chris Greenman: Cancer Genome Project, Wellcome Trust Sanger Institute
Lina Chen: Cancer Genome Project, Wellcome Trust Sanger Institute
Graham Bignell: Cancer Genome Project, Wellcome Trust Sanger Institute
Adam Butler: Cancer Genome Project, Wellcome Trust Sanger Institute
Helen Davies: Cancer Genome Project, Wellcome Trust Sanger Institute
Sarah Edkins: Cancer Genome Project, Wellcome Trust Sanger Institute
Claire Hardy: Cancer Genome Project, Wellcome Trust Sanger Institute
Calli Latimer: Cancer Genome Project, Wellcome Trust Sanger Institute
Jon Teague: Cancer Genome Project, Wellcome Trust Sanger Institute
Jenny Andrews: Cancer Genome Project, Wellcome Trust Sanger Institute
Syd Barthorpe: Cancer Genome Project, Wellcome Trust Sanger Institute
Dave Beare: Cancer Genome Project, Wellcome Trust Sanger Institute
Gemma Buck: Cancer Genome Project, Wellcome Trust Sanger Institute
Peter J. Campbell: Cancer Genome Project, Wellcome Trust Sanger Institute
Simon Forbes: Cancer Genome Project, Wellcome Trust Sanger Institute
Mingming Jia: Cancer Genome Project, Wellcome Trust Sanger Institute
David Jones: Cancer Genome Project, Wellcome Trust Sanger Institute
Henry Knott: Cancer Genome Project, Wellcome Trust Sanger Institute
Chai Yin Kok: Cancer Genome Project, Wellcome Trust Sanger Institute
King Wai Lau: Cancer Genome Project, Wellcome Trust Sanger Institute
Catherine Leroy: Cancer Genome Project, Wellcome Trust Sanger Institute
Meng-Lay Lin: Cancer Genome Project, Wellcome Trust Sanger Institute
David J. McBride: Cancer Genome Project, Wellcome Trust Sanger Institute
Mark Maddison: Cancer Genome Project, Wellcome Trust Sanger Institute
Simon Maguire: Cancer Genome Project, Wellcome Trust Sanger Institute
Kirsten McLay: Cancer Genome Project, Wellcome Trust Sanger Institute
Andrew Menzies: Cancer Genome Project, Wellcome Trust Sanger Institute
Tatiana Mironenko: Cancer Genome Project, Wellcome Trust Sanger Institute
Lee Mulderrig: Cancer Genome Project, Wellcome Trust Sanger Institute
Laura Mudie: Cancer Genome Project, Wellcome Trust Sanger Institute
Sarah O’Meara: Cancer Genome Project, Wellcome Trust Sanger Institute
Erin Pleasance: Cancer Genome Project, Wellcome Trust Sanger Institute
Arjunan Rajasingham: Cancer Genome Project, Wellcome Trust Sanger Institute
Rebecca Shepherd: Cancer Genome Project, Wellcome Trust Sanger Institute
Raffaella Smith: Cancer Genome Project, Wellcome Trust Sanger Institute
Lucy Stebbings: Cancer Genome Project, Wellcome Trust Sanger Institute
Philip Stephens: Cancer Genome Project, Wellcome Trust Sanger Institute
Gurpreet Tang: Cancer Genome Project, Wellcome Trust Sanger Institute
Patrick S. Tarpey: Cancer Genome Project, Wellcome Trust Sanger Institute
Kelly Turrell: Cancer Genome Project, Wellcome Trust Sanger Institute
Karl J. Dykema: Laboratory of Computational Biology,
Sok Kean Khoo: Laboratory of Cancer Genertics, Van Andel Research Institute, Grand Rapids, Michigan 49503, USA
David Petillo: Laboratory of Cancer Genertics, Van Andel Research Institute, Grand Rapids, Michigan 49503, USA
Bill Wondergem: Laboratory of Computational Biology,
John Anema: Spectrum Health Hospital, Grand Rapids, Michigan 49503, USA
Richard J. Kahnoski: Spectrum Health Hospital, Grand Rapids, Michigan 49503, USA
Bin Tean Teh: Laboratory of Cancer Genertics, Van Andel Research Institute, Grand Rapids, Michigan 49503, USA
Michael R. Stratton: Cancer Genome Project, Wellcome Trust Sanger Institute
P. Andrew Futreal: Cancer Genome Project, Wellcome Trust Sanger Institute

Nature, 2010, vol. 463, issue 7279, 360-363

Abstract: Chromatin modification in renal carcinoma A large survey for somatic mutations in clear cell renal cell carcinomas, the most common form of adult kidney cancer, shows that in addition to the known inactivating mutations in the VHL gene, recurrent mutations occur in the NF2 gene, which encodes a tumour suppressor protein and in genes encoding the chromatin modifying enzymes SETD2, JARID1C and UTX.

Date: 2010
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/nature08672 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:463:y:2010:i:7279:d:10.1038_nature08672

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature08672

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().