Transcriptional role of cyclin D1 in development revealed by a genetic–proteomic screen

Frédéric Bienvenu, Siwanon Jirawatnotai, Joshua E. Elias, Clifford A. Meyer, Karolina Mizeracka, Alexander Marson, Garrett M. Frampton, Megan F. Cole, Duncan T. Odom, Junko Odajima, Yan Geng, Agnieszka Zagozdzon, Marie Jecrois, Richard A. Young, X. Shirley Liu, Constance L. Cepko, Steven P. Gygi and Piotr Sicinski ()
Additional contact information
Frédéric Bienvenu: Dana-Farber Cancer Institute, Harvard Medical School
Siwanon Jirawatnotai: Dana-Farber Cancer Institute, Harvard Medical School
Joshua E. Elias: Harvard Medical School
Clifford A. Meyer: Dana-Farber Cancer Institute and Harvard School of Public Health
Karolina Mizeracka: Harvard Medical School, Boston, Massachusetts 02115, USA
Alexander Marson: Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
Garrett M. Frampton: Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
Megan F. Cole: Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
Duncan T. Odom: Cancer Research UK-Cambridge Research Institute, Li Ka Shing Centre, Cambridge CB2 0RE, UK
Junko Odajima: Dana-Farber Cancer Institute, Harvard Medical School
Yan Geng: Dana-Farber Cancer Institute, Harvard Medical School
Agnieszka Zagozdzon: Dana-Farber Cancer Institute, Harvard Medical School
Marie Jecrois: Dana-Farber Cancer Institute, Harvard Medical School
Richard A. Young: Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
X. Shirley Liu: Dana-Farber Cancer Institute and Harvard School of Public Health
Constance L. Cepko: Harvard Medical School, Boston, Massachusetts 02115, USA
Steven P. Gygi: Harvard Medical School
Piotr Sicinski: Dana-Farber Cancer Institute, Harvard Medical School

Nature, 2010, vol. 463, issue 7279, 374-378

Abstract: Cyclin D1 in development A proteomics approach to screening for cyclin D1-binding proteins in various mouse organs reveals proteins involved in transcription regulation. Cyclin D1 is found to be associated with the promoter regions of many genes, and a role for cyclin D1 in regulating Notch1 gene expression in the developing mouse retina is dissected in detail. These findings suggest that cyclin D1 has a transcription regulatory function during development, in addition to its well-established cell-cycle roles.

Date: 2010
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DOI: 10.1038/nature08684

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