FOXO-dependent regulation of innate immune homeostasis

Thomas Becker, Gerrit Loch, Marc Beyer, Ingo Zinke, Anna C. Aschenbrenner, Pilar Carrera, Therese Inhester, Joachim L. Schultze and Michael Hoch ()
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Thomas Becker: Development, Genetics & Molecular Physiology Unit,
Gerrit Loch: Development, Genetics & Molecular Physiology Unit,
Marc Beyer: Molecular Immune & Cell Biology Unit, LIMES Institute, University of Bonn, Carl-Troll-Strasse 31, D-53115 Bonn, Germany
Ingo Zinke: Development, Genetics & Molecular Physiology Unit,
Anna C. Aschenbrenner: Development, Genetics & Molecular Physiology Unit,
Pilar Carrera: Development, Genetics & Molecular Physiology Unit,
Therese Inhester: Molecular Immune & Cell Biology Unit, LIMES Institute, University of Bonn, Carl-Troll-Strasse 31, D-53115 Bonn, Germany
Joachim L. Schultze: Molecular Immune & Cell Biology Unit, LIMES Institute, University of Bonn, Carl-Troll-Strasse 31, D-53115 Bonn, Germany
Michael Hoch: Development, Genetics & Molecular Physiology Unit,

Nature, 2010, vol. 463, issue 7279, 369-373

Abstract: FOXO transcription factor in innate immunity Most multicellular organisms depend on innate immunity, an ancient host defence mechanism found in both plants and animals, to fight microbial infections. Evolutionarily conserved pathways such as the Toll/Toll-like receptor and immune deficiency and tumour necrosis factor receptor pathways generate antimicrobial peptides as part of the innate immune response. This paper provides evidence that the transcription factor FOXO regulates the expression of antimicrobial peptide genes in Drosophila in response to starvation by an innate immunity independent mechanism. FOXO-dependent regulation of antimicrobial peptide expression is evolutionarily conserved in human lung, kidney and epidermis cells, suggesting that this pathway may be pivotal to maintain the epithelial defence barriers of these cells.

Date: 2010
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DOI: 10.1038/nature08698

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