Innate production of TH2 cytokines by adipose tissue-associated c-Kit+Sca-1+ lymphoid cells

Kazuyo Moro, Taketo Yamada, Masanobu Tanabe, Tsutomu Takeuchi, Tomokatsu Ikawa, Hiroshi Kawamoto, Jun-ichi Furusawa, Masashi Ohtani, Hideki Fujii and Shigeo Koyasu ()
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Kazuyo Moro: Department of Microbiology and Immunology,
Taketo Yamada: Department of Pathology,
Masanobu Tanabe: Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan
Tsutomu Takeuchi: Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan
Tomokatsu Ikawa: Laboratory for Lymphocyte Development, Riken Research Center for Allergy and Immunology, Yokohama, Kanagawa 230-0045, Japan
Hiroshi Kawamoto: Laboratory for Lymphocyte Development, Riken Research Center for Allergy and Immunology, Yokohama, Kanagawa 230-0045, Japan
Jun-ichi Furusawa: Department of Microbiology and Immunology,
Masashi Ohtani: Department of Microbiology and Immunology,
Hideki Fujii: Department of Microbiology and Immunology,
Shigeo Koyasu: Department of Microbiology and Immunology,

Nature, 2010, vol. 463, issue 7280, 540-544

Abstract: Natural helper cells Natural killer cells are innate immune cells that react to viral and bacterial infections by producing various cytokines. Moro et al. report the presence in the mesenteric lymphoid nodules of a previously unrecognized subset of innate lymphoid cells which produce TH2 cytokines and act as helpers for B1 cells. These natural helper cells may play a role in defence against helminths through the activation of mucus production by goblet cells.

Date: 2010
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DOI: 10.1038/nature08636

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