DNMT1 maintains progenitor function in self-renewing somatic tissue

George L. Sen, Jason A. Reuter, Daniel E. Webster, Lilly Zhu and Paul A. Khavari ()
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George L. Sen: Programs in Epithelial Biology and Cancer Biology and the Stanford Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, California 94305, USA
Jason A. Reuter: Programs in Epithelial Biology and Cancer Biology and the Stanford Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, California 94305, USA
Daniel E. Webster: Programs in Epithelial Biology and Cancer Biology and the Stanford Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, California 94305, USA
Lilly Zhu: Programs in Epithelial Biology and Cancer Biology and the Stanford Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, California 94305, USA
Paul A. Khavari: Programs in Epithelial Biology and Cancer Biology and the Stanford Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, California 94305, USA

Nature, 2010, vol. 463, issue 7280, 563-567

Abstract: Self-renewal preserved In self-renewing mammalian epithelial tissues, which are the sites of many degenerative disorders and human malignancies, the gene regulatory basis for the progenitor cells that maintain the tissues and suppress cell-cycle exit and differentiation is unclear. Khavari and colleagues now show that the DNA methyltransferase DNMT1 and other regulators of DNA methylation are essential for epidermal progenitor cell function, being required to sustain proliferation and suppress differentiation.

Date: 2010
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DOI: 10.1038/nature08683

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