Chimpanzee and human Y chromosomes are remarkably divergent in structure and gene content

Jennifer F. Hughes, Helen Skaletsky, Tatyana Pyntikova, Tina A. Graves, Saskia K. M. van Daalen, Patrick J. Minx, Robert S. Fulton, Sean D. McGrath, Devin P. Locke, Cynthia Friedman, Barbara J. Trask, Elaine R. Mardis, Wesley C. Warren, Sjoerd Repping, Steve Rozen, Richard K. Wilson and David C. Page ()
Additional contact information
Jennifer F. Hughes: Howard Hughes Medical Institute, Whitehead Institute, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
Helen Skaletsky: Howard Hughes Medical Institute, Whitehead Institute, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
Tatyana Pyntikova: Howard Hughes Medical Institute, Whitehead Institute, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
Tina A. Graves: The Genome Center, Washington University School of Medicine, 4444 Forest Park Boulevard, St Louis, Missouri 63108, USA
Saskia K. M. van Daalen: Center for Reproductive Medicine, Academic Medical Center
Patrick J. Minx: The Genome Center, Washington University School of Medicine, 4444 Forest Park Boulevard, St Louis, Missouri 63108, USA
Robert S. Fulton: The Genome Center, Washington University School of Medicine, 4444 Forest Park Boulevard, St Louis, Missouri 63108, USA
Sean D. McGrath: The Genome Center, Washington University School of Medicine, 4444 Forest Park Boulevard, St Louis, Missouri 63108, USA
Devin P. Locke: The Genome Center, Washington University School of Medicine, 4444 Forest Park Boulevard, St Louis, Missouri 63108, USA
Cynthia Friedman: Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North C3-168, Seattle, Washington 98109, USA
Barbara J. Trask: Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North C3-168, Seattle, Washington 98109, USA
Elaine R. Mardis: The Genome Center, Washington University School of Medicine, 4444 Forest Park Boulevard, St Louis, Missouri 63108, USA
Wesley C. Warren: The Genome Center, Washington University School of Medicine, 4444 Forest Park Boulevard, St Louis, Missouri 63108, USA
Sjoerd Repping: Center for Reproductive Medicine, Academic Medical Center
Steve Rozen: Howard Hughes Medical Institute, Whitehead Institute, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
Richard K. Wilson: The Genome Center, Washington University School of Medicine, 4444 Forest Park Boulevard, St Louis, Missouri 63108, USA
David C. Page: Howard Hughes Medical Institute, Whitehead Institute, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA

Nature, 2010, vol. 463, issue 7280, 536-539

Abstract: The Y factor With the sequencing of the male-specific region of the chimpanzee Y chromosome, it is now possible to make comparisons with the human Y sequence and to learn more about the recent evolution of the human Y chromosome. The two sequences differ markedly in structure and gene content, indicating rapid evolution during the past 6 million years. This finding is at odds with the common view that Y chromosomes are essentially static structures that evolve only very slowly by genetic loss. Rather, renovation and remodelling dominate the evolution of human and chimpanzee Y chromosomes. Possible reasons for this extraordinary divergence include genetic hitchhiking effects, species-specific mating behaviours and the Y chromosome's role in sperm production.

Date: 2010
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DOI: 10.1038/nature08700

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