Interaction between RasV12 and scribbled clones induces tumour growth and invasion

Ming Wu, José Carlos Pastor-Pareja and Tian Xu ()
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Ming Wu: Howard Hughes Medical Institute, Yale University School of Medicine, 295 Congress Avenue, New Haven, Connecticut 06519, USA
José Carlos Pastor-Pareja: Howard Hughes Medical Institute, Yale University School of Medicine, 295 Congress Avenue, New Haven, Connecticut 06519, USA
Tian Xu: Howard Hughes Medical Institute, Yale University School of Medicine, 295 Congress Avenue, New Haven, Connecticut 06519, USA

Nature, 2010, vol. 463, issue 7280, 545-548

Abstract: Cell–cell communication in tumours In a genetically well-defined model system in Drosophila, Tian Xu and colleagues show that cell clones carrying distinct oncogenic mutations can cooperate to produce invasive tumours. This cooperation involves JNK and JAK/STAT signalling pathways. Similar cooperative mechanism might be at play in the communication between genetically heterogeneous human cancer cells or between tumour cells and their microenvironment.

Date: 2010
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DOI: 10.1038/nature08702

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