A role for the elongator complex in zygotic paternal genome demethylation

Yuki Okada, Kazuo Yamagata, Kwonho Hong, Teruhiko Wakayama and Yi Zhang ()
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Yuki Okada: Howard Hughes Medical Institute,
Kazuo Yamagata: Laboratory for Genomic Reprogramming, Center for Developmental Biology, RIKEN, 2-2-3 Minatojima-minamimachi, Chuo-ku, Kobe 650-0047, Japan
Kwonho Hong: Howard Hughes Medical Institute,
Teruhiko Wakayama: Laboratory for Genomic Reprogramming, Center for Developmental Biology, RIKEN, 2-2-3 Minatojima-minamimachi, Chuo-ku, Kobe 650-0047, Japan
Yi Zhang: Howard Hughes Medical Institute,

Nature, 2010, vol. 463, issue 7280, 554-558

Abstract: Elongator in zygotic paternal genome demethylation After fertilization in mammals, the maternal and paternal genomes undergo epigenetic reprogramming to prepare for the transition from germ cell to somatic cell transcription programs. One of the events involved in this process is the rapid demethylation of the paternal genome. To identify factors involved in this process, a live-cell imaging system was developed to monitor paternal DNA methylation state in zygotes. Elp3, a component of the elongator complex, is found to be important for paternal DNA demethylation.

Date: 2010
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DOI: 10.1038/nature08732

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