Expansion of the eukaryotic proteome by alternative splicing

Timothy W. Nilsen and Brenton R. Graveley
Additional contact information
Timothy W. Nilsen: Center for RNA Molecular Biology, Case Western Reserve University, School of Medicine
Brenton R. Graveley: University of Connecticut Stem Cell Institute, University of Connecticut Health Center

Nature, 2010, vol. 463, issue 7280, 457-463

Abstract: Abstract The collection of components required to carry out the intricate processes involved in generating and maintaining a living, breathing and, sometimes, thinking organism is staggeringly complex. Where do all of the parts come from? Early estimates stated that about 100,000 genes would be required to make up a mammal; however, the actual number is less than one-quarter of that, barely four times the number of genes in budding yeast. It is now clear that the 'missing' information is in large part provided by alternative splicing, the process by which multiple different functional messenger RNAs, and therefore proteins, can be synthesized from a single gene.

Date: 2010
References: Add references at CitEc
Citations: View citations in EconPapers (12)

Downloads: (external link)
https://www.nature.com/articles/nature08909 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:463:y:2010:i:7280:d:10.1038_nature08909

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature08909

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().