The endocytic matrix

Giorgio Scita and Pier Paolo Di Fiore
Additional contact information
Giorgio Scita: IFOM, the FIRC Institute for Molecular Oncology Foundation, at the IFOM-IEO Campus
Pier Paolo Di Fiore: IFOM, the FIRC Institute for Molecular Oncology Foundation, at the IFOM-IEO Campus

Nature, 2010, vol. 463, issue 7280, 464-473

Abstract: Abstract Endocytosis has long been thought of as simply a way for cells to internalize nutrients and membrane-associated molecules. But an explosive growth in knowledge has given a new dimension to our understanding of this process. It now seems that endocytosis is a master organizer of signalling circuits, with one of its main roles being the resolution of signals in space and time. Many of the functions of endocytosis that are emerging from recent research cannot yet be reconciled with the canonical view of intracellular trafficking but, instead, point to endocytosis being integrated at a deeper level in the cellular 'master plan' (the cellular network of signalling circuits that lie at the base of the cell's make-up). Deconvolution of this level, which we call the 'endocytic matrix', might uncover a fundamental aspect of how a cell is built.

Date: 2010
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/nature08910 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:463:y:2010:i:7280:d:10.1038_nature08910

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature08910

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().