Towards building a chromosome segregation machine

Kerry Bloom and Ajit Joglekar
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Kerry Bloom: 622 Fordham Hall, CB3280, University of North Carolina at Chapel Hill
Ajit Joglekar: 622 Fordham Hall, CB3280, University of North Carolina at Chapel Hill

Nature, 2010, vol. 463, issue 7280, 446-456

Abstract: Abstract All organisms, from bacteria to humans, face the daunting task of replicating, packaging and segregating up to two metres (about 6 × 109 base pairs) of DNA when each cell divides. This task is carried out up to a trillion times during the development of a human from a single fertilized cell. The strategy by which DNA is replicated is now well understood. But when it comes to packaging and segregating a genome, the mechanisms are only beginning to be understood and are often as variable as the organisms in which they are studied.

Date: 2010
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DOI: 10.1038/nature08912

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