Multiple native states reveal persistent ruggedness of an RNA folding landscape

Sergey V. Solomatin, Max Greenfeld, Steven Chu and Daniel Herschlag ()
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Sergey V. Solomatin: Department of Biochemistry,
Max Greenfeld: Stanford University, Stanford, California 94305, USA
Steven Chu: Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
Daniel Herschlag: Department of Biochemistry,

Nature, 2010, vol. 463, issue 7281, 681-684

Abstract: Funnel vision: RNA folding and refolding Just as the funnel hypothesis is used to describe protein folding, it has been suggested that the process of RNA folding involves a rugged energy terrain in which the molecule samples different valleys until it finds the single lowest-energy state — the global minimum. In this study, Solomatin et al. report the surprising finding that a group I intron RNA can stably exist in one of several catalytically active native states (representing local minima). These RNA conformations are able to interconvert, which promises interesting new avenues of study to determine how this occurs, and how the different native states vary at the molecular level.

Date: 2010
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DOI: 10.1038/nature08717

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