Human host factors required for influenza virus replication

Renate König, Silke Stertz, Yingyao Zhou, Atsushi Inoue, H. -Heinrich Hoffmann, Suchita Bhattacharyya, Judith G. Alamares, Donna M. Tscherne, Mila B. Ortigoza, Yuhong Liang, Qinshan Gao, Shane E. Andrews, Sourav Bandyopadhyay, Paul De Jesus, Buu P. Tu, Lars Pache, Crystal Shih, Anthony Orth, Ghislain Bonamy, Loren Miraglia, Trey Ideker, Adolfo García-Sastre, John A. T. Young, Peter Palese, Megan L. Shaw () and Sumit K. Chanda ()
Additional contact information
Renate König: Infectious and Inflammatory Disease Center, Burnham Institute for Medical Research, 10901 North Torrey Pines Road,
Silke Stertz: Department of Microbiology,
Yingyao Zhou: Genomics Institute of the Novartis Research Foundation, 10675 John J Hopkins Drive, San Diego, California 92121, USA
Atsushi Inoue: Infectious and Inflammatory Disease Center, Burnham Institute for Medical Research, 10901 North Torrey Pines Road,
H. -Heinrich Hoffmann: Department of Microbiology,
Suchita Bhattacharyya: Nomis Center for Immunobiology and Microbial Pathogenesis, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road,
Judith G. Alamares: Department of Microbiology,
Donna M. Tscherne: Department of Microbiology,
Mila B. Ortigoza: Department of Microbiology,
Yuhong Liang: Department of Microbiology,
Qinshan Gao: Department of Microbiology,
Shane E. Andrews: Gene Expression Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
Sourav Bandyopadhyay: University of California, San Diego, Pharmaceutical Sciences Building, 9500 Gilman Drive, La Jolla, California 92093, USA
Paul De Jesus: Infectious and Inflammatory Disease Center, Burnham Institute for Medical Research, 10901 North Torrey Pines Road,
Buu P. Tu: Genomics Institute of the Novartis Research Foundation, 10675 John J Hopkins Drive, San Diego, California 92121, USA
Lars Pache: Infectious and Inflammatory Disease Center, Burnham Institute for Medical Research, 10901 North Torrey Pines Road,
Crystal Shih: Infectious and Inflammatory Disease Center, Burnham Institute for Medical Research, 10901 North Torrey Pines Road,
Anthony Orth: Genomics Institute of the Novartis Research Foundation, 10675 John J Hopkins Drive, San Diego, California 92121, USA
Ghislain Bonamy: Genomics Institute of the Novartis Research Foundation, 10675 John J Hopkins Drive, San Diego, California 92121, USA
Loren Miraglia: Genomics Institute of the Novartis Research Foundation, 10675 John J Hopkins Drive, San Diego, California 92121, USA
Trey Ideker: University of California, San Diego, Pharmaceutical Sciences Building, 9500 Gilman Drive, La Jolla, California 92093, USA
Adolfo García-Sastre: Department of Microbiology,
John A. T. Young: Nomis Center for Immunobiology and Microbial Pathogenesis, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road,
Peter Palese: Department of Microbiology,
Megan L. Shaw: Department of Microbiology,
Sumit K. Chanda: Infectious and Inflammatory Disease Center, Burnham Institute for Medical Research, 10901 North Torrey Pines Road,

Nature, 2010, vol. 463, issue 7282, 813-817

Abstract: Host factors in flu infectivity Two genome-wide RNA interference screens published in this issue identify human host factors required for influenza A virus replication in lung epithelia cell lines. König et al. identify 295 host genes required for influenza replication. Of those, 219 are required for efficient wild-type virus growth, and 23 are required for viral entry. Karlas et al. report the discovery of 287 host genes influencing virus replication. An independent assay confirmed 168 hits (59%) inhibiting either the endemic H1N1 (119 hits) or the current pandemic swine-origin (121 hits) influenza A virus strains, with an overlap of 60%. These studies should provide a number of potential targets for host factor-directed antivirals for treatment of influenza viral infection.

Date: 2010
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DOI: 10.1038/nature08699

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