Mical links semaphorins to F-actin disassembly

Ruei-Jiun Hung, Umar Yazdani, Jimok Yoon, Heng Wu, Taehong Yang, Nidhi Gupta, Zhiyu Huang, Willem J. H. van Berkel and Jonathan R. Terman ()
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Ruei-Jiun Hung: The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
Umar Yazdani: The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
Jimok Yoon: The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
Heng Wu: The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
Taehong Yang: The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
Nidhi Gupta: The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
Zhiyu Huang: The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
Willem J. H. van Berkel: Laboratory of Biochemistry, Wageningen University, Dreijenlaan 3, 6703 HA Wageningen, The Netherlands
Jonathan R. Terman: The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA

Nature, 2010, vol. 463, issue 7282, 823-827

Abstract: Mical link for semaphorins and F-actin Semaphorins and plexins relay guidance information to neurons during development and regulate actin dynamics through an unknown mechanism. In recent studies, a family of oxidoreductase enzymes called Mical were found to associate with plexins and mediate axon guidance. Hung et al. demonstrate that in Drosophila, Mical is an F-actin-binding protein that links plexins and semaphorins to the actin cytoskeleton. Changing the levels of Mical in vivo result in reorganization of the actin cytoskeleton, indicating that Mical is required for maintaining the normal size and organization of F-actin bundles. Thus, plexins on the cell surface modulate the actin cytoskeleton via the Mical oxidoreductase.

Date: 2010
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DOI: 10.1038/nature08724

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