Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate

Ye Zheng, Steven Josefowicz, Ashutosh Chaudhry, Xiao P. Peng, Katherine Forbush and Alexander Y. Rudensky ()
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Ye Zheng: University of Washington, Seattle, Washington 98195, USA
Steven Josefowicz: University of Washington, Seattle, Washington 98195, USA
Ashutosh Chaudhry: University of Washington, Seattle, Washington 98195, USA
Xiao P. Peng: Howard Hughes Medical Institute and Immunology Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA
Katherine Forbush: University of Washington, Seattle, Washington 98195, USA
Alexander Y. Rudensky: University of Washington, Seattle, Washington 98195, USA

Nature, 2010, vol. 463, issue 7282, 808-812

Abstract: Foxp3 gene and T-cell fate Regulatory T (Treg) cells act to suppress immune system activation, so tight control over their numbers and activity is an important part of immune homeostasis. Here it is shown that particular conserved non-coding sequence elements at the Foxp3 locus play a role in controlling the size and composition of the Treg-cell population.

Date: 2010
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DOI: 10.1038/nature08750

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