Genome-wide RNAi screen identifies human host factors crucial for influenza virus replication

Alexander Karlas, Nikolaus Machuy, Yujin Shin, Klaus-Peter Pleissner, Anita Artarini, Dagmar Heuer, Daniel Becker, Hany Khalil, Lesley A. Ogilvie, Simone Hess, André P. Mäurer, Elke Müller, Thorsten Wolff, Thomas Rudel and Thomas F. Meyer ()
Additional contact information
Alexander Karlas: Molecular Biology Department,
Nikolaus Machuy: Molecular Biology Department,
Yujin Shin: Molecular Biology Department,
Klaus-Peter Pleissner: Core Facility Bioinformatics, Max Planck Institute for Infection Biology, Charitéplatz 1, 10117 Berlin, Germany
Anita Artarini: Molecular Biology Department,
Dagmar Heuer: Molecular Biology Department,
Daniel Becker: Molecular Biology Department,
Hany Khalil: Molecular Biology Department,
Lesley A. Ogilvie: Molecular Biology Department,
Simone Hess: Molecular Biology Department,
André P. Mäurer: Molecular Biology Department,
Elke Müller: Molecular Biology Department,
Thorsten Wolff: Robert Koch-Institute, Nordufer 20, 13353 Berlin, Germany
Thomas Rudel: Molecular Biology Department,
Thomas F. Meyer: Molecular Biology Department,

Nature, 2010, vol. 463, issue 7282, 818-822

Abstract: Host factors in flu infectivity Two genome-wide RNA interference screens published in this issue identify human host factors required for influenza A virus replication in lung epithelia cell lines. König et al. identify 295 host genes required for influenza replication. Of those, 219 are required for efficient wild-type virus growth, and 23 are required for viral entry. Karlas et al. report the discovery of 287 host genes influencing virus replication. An independent assay confirmed 168 hits (59%) inhibiting either the endemic H1N1 (119 hits) or the current pandemic swine-origin (121 hits) influenza A virus strains, with an overlap of 60%. These studies should provide a number of potential targets for host factor-directed antivirals for treatment of influenza viral infection.

Date: 2010
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DOI: 10.1038/nature08760

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