TCR–peptide–MHC interactions in situ show accelerated kinetics and increased affinity

Johannes B. Huppa, Markus Axmann, Manuel A. Mörtelmaier, Björn F. Lillemeier, Evan W. Newell, Mario Brameshuber, Lawrence O. Klein, Gerhard J. Schütz and Mark M. Davis ()
Additional contact information
Johannes B. Huppa: Stanford School of Medicine, and
Markus Axmann: Institut für Biophysik, Johannes Kepler-Universität, Altenbergerstrasse 69, A-4040 Linz, Austria
Manuel A. Mörtelmaier: Stanford School of Medicine, and
Björn F. Lillemeier: Stanford School of Medicine, and
Evan W. Newell: Stanford School of Medicine, and
Mario Brameshuber: Institut für Biophysik, Johannes Kepler-Universität, Altenbergerstrasse 69, A-4040 Linz, Austria
Lawrence O. Klein: Stanford School of Medicine, and
Gerhard J. Schütz: Institut für Biophysik, Johannes Kepler-Universität, Altenbergerstrasse 69, A-4040 Linz, Austria
Mark M. Davis: Stanford School of Medicine, and

Nature, 2010, vol. 463, issue 7283, 963-967

Abstract: T-cell interactions The use of a novel FRET-based imaging system provides an in situ view of the kinetics of T-cell receptor (TCR) binding to peptide MHC complexes in their natural environment, the immunological synapse. Previously the mater of how containment in this environment would affect the molecular interactions that drive cell–cell interactions has been a matter of speculation. Now that they have been measured, both expected effects (enhanced association rate due to optimal orientation) and unexpected (a very active cytoskeletal component destabilizing TCR binding) are revealed. This work is of relevance to T-cell immunology and to in cell–cell interactions more generally.

Date: 2010
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DOI: 10.1038/nature08746

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