Rere controls retinoic acid signalling and somite bilateral symmetry

Gonçalo C. Vilhais-Neto, Mitsuji Maruhashi, Karen T. Smith, Mireille Vasseur-Cognet, Andrew S. Peterson, Jerry L. Workman and Olivier Pourquié ()
Additional contact information
Gonçalo C. Vilhais-Neto: Stowers Institute for Medical Research,
Mitsuji Maruhashi: Stowers Institute for Medical Research,
Karen T. Smith: Stowers Institute for Medical Research,
Mireille Vasseur-Cognet: Metabolism, and Cancer, Institut Cochin, Université Paris Descartes, CNRS (UMR 8104), Inserm U567, Paris, France
Andrew S. Peterson: Genentech, South San Francisco, California 94080, USA
Jerry L. Workman: Stowers Institute for Medical Research,
Olivier Pourquié: Stowers Institute for Medical Research,

Nature, 2010, vol. 463, issue 7283, 953-957

Abstract: Bilateral symmetry The skeletal muscles and vertebrae of the vertebrate body plan show striking bilateral symmetry although this is disrupted in conditions like scoliosis, in which the spine becomes curved. This paper provides insight as to how this symmetry is maintained. A mutation in the Rere (atrophin2) gene is shown to lead to the formation of asymmetrical somites. In addition, Rere controls retinoic acid signalling, which is required to maintain somite symmetry by interacting with Fgf8 in the left–right signalling pathway. Rere forms a complex with Nr2f2, p300 and the retinoic acid receptor (RAR), and this complex is recruited to the retinoic acid regulatory element (RARE) of retinoic acid targets.

Date: 2010
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DOI: 10.1038/nature08763

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