Enzyme-inhibitor-like tuning of Ca2+ channel connectivity with calmodulin

Xiaodong Liu, Philemon S. Yang, Wanjun Yang and David T. Yue ()
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Xiaodong Liu: Calcium Signals Laboratory, The Johns Hopkins University School of Medicine, Ross Building, Room 713, 720 Rutland Avenue, Baltimore, Maryland 21205, USA
Philemon S. Yang: Calcium Signals Laboratory, The Johns Hopkins University School of Medicine, Ross Building, Room 713, 720 Rutland Avenue, Baltimore, Maryland 21205, USA
Wanjun Yang: Calcium Signals Laboratory, The Johns Hopkins University School of Medicine, Ross Building, Room 713, 720 Rutland Avenue, Baltimore, Maryland 21205, USA
David T. Yue: Calcium Signals Laboratory, The Johns Hopkins University School of Medicine, Ross Building, Room 713, 720 Rutland Avenue, Baltimore, Maryland 21205, USA

Nature, 2010, vol. 463, issue 7283, 968-972

Abstract: Calcium channel tuning Calcium channels and calmodulin are prominent hubs of biological signalling networks, with each calcium channel associating with its own calmodulin. Calmodulin acts as a Ca2+ sensor, regulating Ca2+ entry through the channel. This paper shows that certain CaV1.3 and CaV1.4 channels contain a module that resembles an enzyme competitive inhibitor, retuning channel affinity so that natural variations of calmodulin expression can modulate Ca2+ feedback regulation of channels.

Date: 2010
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DOI: 10.1038/nature08766

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