Tbx3 improves the germ-line competency of induced pluripotent stem cells

Jianyong Han, Ping Yuan, Henry Yang, Jinqiu Zhang, Boon Seng Soh, Pin Li, Siew Lan Lim, Suying Cao, Junliang Tay, Yuriy L. Orlov, Thomas Lufkin, Huck-Hui Ng, Wai-Leong Tam () and Bing Lim ()
Additional contact information
Jianyong Han: Stem Cell and Developmental Biology,
Ping Yuan: Stem Cell and Developmental Biology,
Henry Yang: Singapore Immunology Network, 138648, Singapore
Jinqiu Zhang: Stem Cell and Developmental Biology,
Boon Seng Soh: Stem Cell and Developmental Biology,
Pin Li: Stem Cell and Developmental Biology,
Siew Lan Lim: Stem Cell and Developmental Biology,
Suying Cao: Stem Cell and Developmental Biology,
Junliang Tay: Stem Cell and Developmental Biology,
Yuriy L. Orlov: Systems Biology, Genome Institute of Singapore, 138672, Singapore
Thomas Lufkin: Stem Cell and Developmental Biology,
Huck-Hui Ng: Stem Cell and Developmental Biology,
Wai-Leong Tam: Stem Cell and Developmental Biology,
Bing Lim: Stem Cell and Developmental Biology,

Nature, 2010, vol. 463, issue 7284, 1096-1100

Abstract: Tbx3 boosts iPS quality While much attention has been given to the study of different genetic and chemical methods for the generation of iPS (induced pluripotent stem) cell lines, relatively little is known about the variability in overall quality of iPS cells. This paper identifies a transcription factor, Tbx3, that significantly improves the quality of iPS cells. Tbx3 also accelerates the reprogramming process of mouse embryonic fibroblasts into iPS cells and significantly improves the germ-line transmission of iPS-derived germ cells in chimaeric animals.

Date: 2010
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DOI: 10.1038/nature08735

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