Ancient animal microRNAs and the evolution of tissue identity

Foteini Christodoulou, Florian Raible, Raju Tomer, Oleg Simakov, Kalliopi Trachana, Sebastian Klaus, Heidi Snyman, Gregory J. Hannon, Peer Bork and Detlev Arendt ()
Additional contact information
Foteini Christodoulou: Developmental Biology Unit,
Florian Raible: Developmental Biology Unit,
Raju Tomer: Developmental Biology Unit,
Oleg Simakov: Developmental Biology Unit,
Kalliopi Trachana: Computational Biology Unit, European Molecular Biology Laboratory, D-69117 Heidelberg, Germany
Sebastian Klaus: Developmental Biology Unit,
Heidi Snyman: Developmental Biology Unit,
Gregory J. Hannon: Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA
Peer Bork: Computational Biology Unit, European Molecular Biology Laboratory, D-69117 Heidelberg, Germany
Detlev Arendt: Developmental Biology Unit,

Nature, 2010, vol. 463, issue 7284, 1084-1088

Abstract: An oral tradition for microRNA Recent work suggests that microRNAs, the ubiquitous, small, non-coding genetic elements with important regulatory roles, were important in the evolution of complexity in multicellular animals. What was the role of these microRNAs when they first evolved? A deep sequencing study of the marine ragworm Platynereis dumerilii, and comparison with other bilaterian animals, suggests that the most ancient known microRNA, miR-100, was initially active in neurosecretory cells around the mouth. Other highly conserved varieties were first present in specific tissues and organ systems, such as ciliated cells and parts of the nervous system, musculature and gut. This work suggests that the last common ancestor of bilaterian animals already had all these structures.

Date: 2010
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DOI: 10.1038/nature08744

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