Reprogramming towards pluripotency requires AID-dependent DNA demethylation

Nidhi Bhutani, Jennifer J. Brady, Mara Damian, Alessandra Sacco, Stéphane Y. Corbel and Helen M. Blau ()
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Nidhi Bhutani: Baxter Laboratory for Stem Cell Biology, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, California 94305-5175, USA
Jennifer J. Brady: Baxter Laboratory for Stem Cell Biology, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, California 94305-5175, USA
Mara Damian: Baxter Laboratory for Stem Cell Biology, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, California 94305-5175, USA
Alessandra Sacco: Baxter Laboratory for Stem Cell Biology, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, California 94305-5175, USA
Stéphane Y. Corbel: Baxter Laboratory for Stem Cell Biology, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, California 94305-5175, USA
Helen M. Blau: Baxter Laboratory for Stem Cell Biology, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, California 94305-5175, USA

Nature, 2010, vol. 463, issue 7284, 1042-1047

Abstract: Abstract Reprogramming of somatic cell nuclei to yield induced pluripotent stem (iPS) cells makes possible derivation of patient-specific stem cells for regenerative medicine. However, iPS cell generation is asynchronous and slow (2–3 weeks), the frequency is low (

Date: 2010
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DOI: 10.1038/nature08752

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