An essential role for XBP-1 in host protection against immune activation in C. elegans

Claire E. Richardson, Tristan Kooistra and Dennis H. Kim ()
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Claire E. Richardson: Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Tristan Kooistra: Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Dennis H. Kim: Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA

Nature, 2010, vol. 463, issue 7284, 1092-1095

Abstract: XBP-1 a host defence from innate immunity The unfolded protein response (UPR), a signalling pathway activated by the accumulation of unfolded proteins in the endoplasmic reticulum, is known to contribute to the defence against infectious agents and toxins. Here it is shown that activation of innate immunity in Caenorhabditis elegans induces the UPR mediated by X-box binding protein 1 (XBP-1). This points to an ancient, conserved role for the XBP-1-dependent UPR in protecting cells against the endoplasmic reticulum stress generated from an immune response.

Date: 2010
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DOI: 10.1038/nature08762

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