Location of corneal epithelial stem cells

Tung-Tien Sun (), Scheffer C. Tseng and Robert M. Lavker
Additional contact information
Tung-Tien Sun: Dermatology, Pharmacology and Urology, New York University School of Medicine
Scheffer C. Tseng: Ocular Surface Center, Ocular Surface Research and Education Foundation
Robert M. Lavker: Northwestern University, Feinberg School of Medicine

Nature, 2010, vol. 463, issue 7284, E10-E11

Abstract: Abstract Arising from: Majo, F., Rochat, A., Nicolas, M., Jaoude, G. A. & Barrandon, Y. Nature 456, 250–254 (2008).10.1038/nature07406 ; Majo et al. reply The longstanding concept that corneal epithelial stem cells reside mainly in the limbus is supported by the absence of major corneal epithelial differentiation markers, that is, K3 and K12 keratins, in limbal basal cells (these markers are expressed, however, in corneal basal cells, thus distinguishing the mode of keratin expression in corneal epithelium from that of all other stratified epithelia), the centripetal migration of corneal epithelial cells, the exclusive location of slow-cycling cells in the limbal basal layer, the superior in vitro proliferative potential of limbal epithelial cells, and the transplanted limbal cells’ ability to reconstitute corneal epithelium in vivo (reviewed in refs 1–4). Moreover, previous data indicate that corneal and conjunctival epithelia represent two separate cell lineages (reviewed in refs 1–4). Majo et al.5 suggested, however, that corneal and conjunctival epithelia are equipotent, and that identical oligopotent stem cells are present throughout the corneal, limbal and conjunctival epithelia. We point out here that these suggestions are inconsistent with many known growth, differentiation and cell migration properties of the anterior ocular epithelia.

Date: 2010
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/nature08805 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:463:y:2010:i:7284:d:10.1038_nature08805

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature08805

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().