Genome-wide erasure of DNA methylation in mouse primordial germ cells is affected by AID deficiency

Christian Popp, Wendy Dean, Suhua Feng, Shawn J. Cokus, Simon Andrews, Matteo Pellegrini, Steven E. Jacobsen () and Wolf Reik ()
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Christian Popp: Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge CB22 3AT, and Centre for Trophoblast Research, University of Cambridge
Wendy Dean: Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge CB22 3AT, and Centre for Trophoblast Research, University of Cambridge
Suhua Feng: University of California at Los Angeles, Los Angeles, California 90095, USA
Shawn J. Cokus: University of California at Los Angeles, Los Angeles, California 90095, USA
Simon Andrews: Bioinformatics Group, The Babraham Institute
Matteo Pellegrini: University of California at Los Angeles, Los Angeles, California 90095, USA
Steven E. Jacobsen: University of California at Los Angeles, Los Angeles, California 90095, USA
Wolf Reik: Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge CB22 3AT, and Centre for Trophoblast Research, University of Cambridge

Nature, 2010, vol. 463, issue 7284, 1101-1105

Abstract: AID-dependent DNA methylation in primordial germ cells Epigenetic reprogramming including demethylation of DNA occurs in mammalian primordial germ cells (PGCs) and in early embryos, but the extent of this reprogramming and its molecular mechanisms are poorly understood. Here, DNA methylation profiling in PGCs reveals a genome-wide erasure of methylation, with female PGCs being less methylated than male ones. A deficiency of the cytidine deaminase AID interferes with the genome-wide erasure of DNA methylation, suggesting that AID has a critical function in epigenetic reprogramming.

Date: 2010
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DOI: 10.1038/nature08829

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