Compensatory evolution in mitochondrial tRNAs navigates valleys of low fitness

Margarita V. Meer, Alexey S. Kondrashov, Yael Artzy-Randrup and Fyodor A. Kondrashov ()
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Margarita V. Meer: Bioinformatics and Genomics Programme, Centre for Genomic Regulation, C/Dr Aiguader 88, Barcelona Biomedical Research Park Building, 08003 Barcelona, Spain
Alexey S. Kondrashov: Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, USA
Yael Artzy-Randrup: Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, USA
Fyodor A. Kondrashov: Bioinformatics and Genomics Programme, Centre for Genomic Regulation, C/Dr Aiguader 88, Barcelona Biomedical Research Park Building, 08003 Barcelona, Spain

Nature, 2010, vol. 464, issue 7286, 279-282

Abstract: The landscape of evolution Evolution from one fitness peak to another fitness peak must either involve transitioning through intermediates of low fitness or skirting round the fitness valley through compensatory mutations elsewhere. Meer et al. use the base pairs in mitochondrial tRNA stems as a model to show that deep fitness valleys can be traversed. They show that transitions between AU and GC pairs have occurred during mammalian evolution without help from genetic drift or mutations elsewhere.

Date: 2010
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DOI: 10.1038/nature08691

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