JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells

Diego Pasini, Paul A. C. Cloos, Julian Walfridsson, Linda Olsson, John-Paul Bukowski, Jens V. Johansen, Mads Bak, Niels Tommerup, Juri Rappsilber and Kristian Helin ()
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Diego Pasini: Biotech Research and Innovation Centre (BRIC),
Paul A. C. Cloos: Biotech Research and Innovation Centre (BRIC),
Julian Walfridsson: Biotech Research and Innovation Centre (BRIC),
Linda Olsson: Biotech Research and Innovation Centre (BRIC),
John-Paul Bukowski: Biotech Research and Innovation Centre (BRIC),
Jens V. Johansen: Biotech Research and Innovation Centre (BRIC),
Mads Bak: Wilhelm Johannsen Centre For Functional Genome Research, University of Copenhagen, Blegdamsvej 3, 2200 Copenhagen N, Denmark
Niels Tommerup: Wilhelm Johannsen Centre For Functional Genome Research, University of Copenhagen, Blegdamsvej 3, 2200 Copenhagen N, Denmark
Juri Rappsilber: Wellcome Trust Centre for Cell Biology, University of Edinburgh
Kristian Helin: Biotech Research and Innovation Centre (BRIC),

Nature, 2010, vol. 464, issue 7286, 306-310

Abstract: Role for JARID2 in embryonic stem cells Polycomb proteins have a key role in regulating the expression of genes essential for development, differentiation and maintenance of cell fates. Here, Polycomb repressive complex 2 (PRC2) is shown to form a complex with JARID2, a Jumonji domain protein. JARID2 is required for the binding of Polycomb proteins to target genes in embryonic stem cells as well as for the proper differentiation of embryonic stem cells and normal development.

Date: 2010
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DOI: 10.1038/nature08788

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