Systematic genetic analysis of muscle morphogenesis and function in Drosophila

Frank Schnorrer (), Cornelia Schönbauer, Christoph C. H. Langer, Georg Dietzl, Maria Novatchkova, Katharina Schernhuber, Michaela Fellner, Anna Azaryan, Martin Radolf, Alexander Stark, Krystyna Keleman and Barry J. Dickson ()
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Frank Schnorrer: Max-Planck-Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany
Cornelia Schönbauer: Max-Planck-Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany
Christoph C. H. Langer: Max-Planck-Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany
Georg Dietzl: Research Institute of Molecular Pathology (IMP), Dr. Bohr-Gasse 7, A-1030 Vienna, Austria
Maria Novatchkova: Research Institute of Molecular Pathology (IMP), Dr. Bohr-Gasse 7, A-1030 Vienna, Austria
Katharina Schernhuber: Research Institute of Molecular Pathology (IMP), Dr. Bohr-Gasse 7, A-1030 Vienna, Austria
Michaela Fellner: Research Institute of Molecular Pathology (IMP), Dr. Bohr-Gasse 7, A-1030 Vienna, Austria
Anna Azaryan: Research Institute of Molecular Pathology (IMP), Dr. Bohr-Gasse 7, A-1030 Vienna, Austria
Martin Radolf: Research Institute of Molecular Pathology (IMP), Dr. Bohr-Gasse 7, A-1030 Vienna, Austria
Alexander Stark: Research Institute of Molecular Pathology (IMP), Dr. Bohr-Gasse 7, A-1030 Vienna, Austria
Krystyna Keleman: Research Institute of Molecular Pathology (IMP), Dr. Bohr-Gasse 7, A-1030 Vienna, Austria
Barry J. Dickson: Research Institute of Molecular Pathology (IMP), Dr. Bohr-Gasse 7, A-1030 Vienna, Austria

Nature, 2010, vol. 464, issue 7286, 287-291

Abstract: Muscle genes catalogued in Drosophila A genome-wide RNAi screen has been used to define the genetic basis for the formation and function of Drosophila muscle. A total of 2,785 genes were recognized as having a role in muscle, many of then assigned to specific functions in the organization of muscles, myofibrils or sarcomeres. Many of these genes are phylogenetically conserved, and the list of conserved and functionally validated muscle genes includes a strong enrichment for genes implicated in mammalian sarcomere organization and human muscle diseases.

Date: 2010
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DOI: 10.1038/nature08799

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