Immunology and the elusive AIDS vaccine

Herbert W. Virgin () and Bruce D. Walker ()
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Herbert W. Virgin: Washington University School of Medicine and Midwest Regional Center of Excellence for Biodefense and Emerging Infectious Disease Research, Campus Box 8118, 660 South Euclid Avenue, Saint Louis, Missouri 63110, USA
Bruce D. Walker: Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Howard Hughes Medical Institute, 149 13th Street, Charlestown, Massachusetts 02129, USA

Nature, 2010, vol. 464, issue 7286, 224-231

Abstract: HIV: complex immunology Several lines of evidence suggest that simply generating an immune response similar to that seen in natural infections is unlikely to protect against HIV/AIDS. With this in mind, Herbert Virgin and Bruce Walker argue that our fundamental approach to HIV vaccination needs to be re-examined. Their review outlines the immunological questions still to be answered if an effective vaccine is to be produced.

Date: 2010
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DOI: 10.1038/nature08898

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