Inhibitors that activate

Karen Cichowski and Pasi A. Jänne
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Karen Cichowski: Brigham and Women's Hospital, Boston, Massachusetts 02115, USA. kcichowski@rics.bwh.harvard.edu
Pasi A. Jänne: Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA. pjanne@partners.org

Nature, 2010, vol. 464, issue 7287, 358-359

Abstract: Inhibitors of RAF enzymes can suppress or activate the same signalling pathway. The details of how this happens provide a cautionary note for those targeting the pathway for anticancer drug discovery.

Date: 2010
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DOI: 10.1038/464358a

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