Differential innate immune signalling via Ca2+ sensor protein kinases

Marie Boudsocq (), Matthew R. Willmann (), Matthew McCormack, Horim Lee, Libo Shan, Ping He, Jenifer Bush, Shu-Hua Cheng and Jen Sheen
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Marie Boudsocq: Massachusetts General Hospital, Massachusetts 02114, USA
Matthew R. Willmann: Massachusetts General Hospital, Massachusetts 02114, USA
Matthew McCormack: Massachusetts General Hospital, Massachusetts 02114, USA
Horim Lee: Massachusetts General Hospital, Massachusetts 02114, USA
Libo Shan: Massachusetts General Hospital, Massachusetts 02114, USA
Ping He: Massachusetts General Hospital, Massachusetts 02114, USA
Jenifer Bush: Massachusetts General Hospital, Massachusetts 02114, USA
Shu-Hua Cheng: Massachusetts General Hospital, Massachusetts 02114, USA
Jen Sheen: Massachusetts General Hospital, Massachusetts 02114, USA

Nature, 2010, vol. 464, issue 7287, 418-422

Abstract: Calcium sensing pivotal in innate immunity Plants and animals sense the invasion of pathogens using pattern recognition receptors that recognize diverse microbe-associated molecular patterns (MAMPs) and initiate innate immune responses. Early signalling events in the host include calcium influx, activation of mitogen-activated protein kinases (MAPKs), oxidative burst and transcriptional reprogramming. Boudsocq et al. use a functional genomic screen and genome-wide gene expression profiling in Arabidopsis to show that four calcium-dependent protein kinases (CDPKs) acting as Ca2+ sensors are the convergence points for diverse MAMPs and are critical for transcriptional reprogramming and oxidative burst in plants.

Date: 2010
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DOI: 10.1038/nature08794

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